卡尔Haushalter
Professor of 化学 and 生物学
Jacobs Science Center, Room 1218
普拉特大道301号.
Claremont, CA 91711
909.607.3928
Karl_Haushalter@sheep-lovely.com
Education and professional experience
- B.A.莱斯大学
- 哈佛大学博士
- 访问ing Lecturer, University of California, Irvine
- Postdoctoral Fellow, University of California, San Diego
教学
- Bio 182: 化学 in Living Systems
- Bio 184: Methods in Biochemistry
- Bio 187: HIV-AIDS: Science, Society and Service
- Bio 189: Topics in Biochemistry and 分子生物学
- 化学21:普通化学
- 化学 25: General 化学 Laboratory
- 化学 58: Carbon Compounds Laboratory
- 化学105:有机化学
- 化学 111: Organic 化学 Laboratory
研究兴趣
Double strand breaks or chemically modified bases in DNA arise from exposure to ionizing radiation, 环境毒素, or mistakes during DNA replication. DNA repair enzymes scan the genome and fix DNA damage to maintain genomic integrity. Studying the details of DNA repair provides an entry point into understanding the molecular mechanisms of carcinogenesis, 老化, 和演化. 学生 in the Haushalter lab utilize biochemical and genetic approaches to study enzymes in the homologous recombination repair pathway and the base excision repair pathway. In addition to these scientific pursuits, Prof. Haushalter is active in community efforts to combat the stigma associated with HIV-AIDS and support those living with HIV-AIDS through education and empowerment. The HIV-AIDS: Science, Society, and Service class taught by Prof. Haushalter is an integrative experience, service-learning course that addresses both the science of HIV and the ways that the HIV epidemic has impacted communities.
近期学生项目
Matthew Hoss (’08) and Sara Hummel (’06): “Sequence Specificity of Human 8-Oxoguanine DNA Glycosylase”
Katie Mouzakis(07届), 闫璞(06年), and Tiffany Wu (’06): “DNA Repair Efficiency of Variants of Human 8-oxoguanine DNA Glycosylase 1 (hOGG1) Identified in Cancer Patients”
Fang-Yuan Chang (’07): “Trapping the hOGG1:nucleosomal DNA complex”
Brianna Lyon-Robers (’06): “Improved methods for in vitro nucleosome reconstitution”
Steven Petesch (’05): “Location mechanism of adenine·8-oxoguanine mismatches by MutY adenine DNA glycosylase”
Sarah Bundick (’05) and Ryan Mashiyama (’04): “Target Location by the DNA Repair Enzyme SMUG1”
Kit Rodolfa (’04): “Synthesis of large fragments of DNA incorporating site-specific base lesions”
Alexis Kaushansky (’04): “Filling in the black box between I-CreI induced DNA cleavage and double-strand break repair”
选定的出版物
Gemmen G. J., R. Sim卡, K. A. Haushalter, P. C. 柯,我. T. Kadonaga和D. E. 史密斯. 2005. Forced unraveling of nucleosomes assembled on heterogeneous DNA using core histones, NAP-1, and ACF. J. 摩尔. 医学杂志. 351: 89-99.
Wibley J. E. A., T. R. 水域, K. Haushalter, G. L. 沃丁和L. H. 珍珠. 2003. Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. 摩尔. 细胞. 11(6): 1647-1659.
K. A. Haushalter 和J. T. Kadonaga. 2003. Chromatin assembly by DNA-translocating motors. Nat. 牧师. 摩尔. 细胞生物. 4(8): 613-620.
L. 陈, K. A. Haushalter, C. M. 利伯和G. L. 沃丁. 2002. Direct visualization of a DNA glycosylase searching for damage. 化学. 医学杂志. 9: 345-350.
H. 流行病学, K. A. Haushalter, P. 知更鸟,D. E. 巴恩斯,G. L. 沃丁和T. 林达尔. 2001. Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil DNA glycosylase. EMBO J. 20: 4278-4286.
K. A. Haushalter, P. T. Stukenberg, M. W. 克什纳和G. L. 沃丁. 1999. Identification of a new uracil DNA glycosylase family by expression cloning using synthetic inhibitors. 咕咕叫. 医学杂志. 9: 174-185.
K. A. Haushalter, J. 刘，J。. D. 罗伯茨. 1996. An NMR investigation of the effect of hydrogen bonding on the rates of rotation about the C-N bonds in urea and thiourea. J. 阿米尔-. 化学. Soc. 118: 8891-8896.